East Coast (US or Canada)
Position Id

GeneCoda has been retained to identify and evaluate candidates for a Director / Senior Director of Medicinal Chemistry to ideally be located on the Eastern Time Zone of the US or Canada.

About Our Client:

Our client partners with pharmaceutical and biotechnology companies in the provision of a holistic solution for screening, hit validation and lead optimization. Our client’s industry leading platform excels at the discovery of novel small molecule leads against challenging, high value therapeutic targets.

Our client’s therapeutic expertise ranges across CNS, oncology, metabolic diseases, and other specialized areas, including structure-based design, GPCR modulators, ion channel modulators and PROTACs.

Our client’s well published leadership team offers a proven track record of advancing projects from initial hit to lead to drug candidate with over a dozen compounds advancing into IND-enabling tox and several reaching Phase I or beyond.


Our client’s experience and platform enables them to collaborate on some of the most challenging and impactful projects in the biopharmaceutical industry. In some cases, our client drives project design exclusively.

Our client offers a stimulating, casual, and fun working environment, plus a competitive salary and benefits package, and the opportunity for all employees to grow with the company.

Our client is seeking an accomplished Director / Senior Director of Medicinal Chemistry with a proven reputation in small molecule drug discovery including leading teams that have driven assets to IND enabling studies.

Key Responsibilities:

  • Implement and drive innovative drug discovery strategies utilizing deep expertise across medicinal chemistry and synthetic chemistry route design, through comprehensive knowledge of DMPK, pharmacology, and safety.
  • Efficiently and expertly drive multi-parameter optimization across multiple projects and across multiple disease areas from hit ID through candidate selection.
  • Lead each drug discovery project team, driving scientific strategy & decision-making, target design & synthesis.
  • Support business development activities through engagement with partners, conference attendance, support the development of case studies, white papers, and marketing material.
  • Prepare research and cost proposals for services.
  • Develop creative solutions to challenging program issues. Contribute as a senior medicinal chemist to scientific problem solving for partners and internal teams.
  • Supervise externalized resources at CROs to expeditiously deliver high quality research results.
  • Supervise internal Project Chemistry Team Leaders, medicinal chemists, and synthetic chemists.

Education: PhD in Synthetic Organic Chemistry or related field.

Experience and Qualifications:

  • 8+ years of experience as a medicinal chemist at a pharmaceutical or biotech company.
  • Demonstrated success as a drug hunter with significant contributions to advancing multiple drug discovery programs from initial hits to development candidates.
  • Experience leading drug discovery project teams.
  • Highly proficient in synthetic and medicinal chemistry. Experience with SBDD, FBDD, DEL, protein degradation, and/or other technology platforms is highly desirable.
  • Strong track record of external publication and presentations demonstrating scientific innovation.
  • Hands-on industrial experience in synthetic chemistry and experience supervising bench chemists is preferred.

Desired Characteristics:

  • Collaborative, organized, data-driven, and detail-oriented.
  • Effective decision-making and problem-solving skills.
  • Ability to prioritize, organize and manage multiple projects simultaneously.
  • Excellent interpersonal skills.
  • Excellent verbal and written communication skills.

GeneCoda refers qualified applicants for all jobs without regard to race, color, religion, creed, age, sex, disability, marital status, national origin, pregnancy, family medical history or genetic information, sexual orientation or preference, Vietnam Era Veteran status or other protected military status or any other status protected by federal, state, or local law.